Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity

Krygier, K.; Wijetunge, A. N.; Srayeddin, A.; Mccann, H.; Rullo, A. F. Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity.” ACS Chem. Biol. 2024, 19 (10), 2103–2117. DOI: 10.1021/acschembio.4c00286

Electrophilic Proximity-Inducing Synthetic Adapters Enhance Universal T Cell Function by Covalently Enforcing Immune Receptor Signaling

Serniuck, N.J.; Kapcan, E.; Moogk, D.; Moore, A.E.; Lake, B.; Denisova, G.; Hammill, J.A.; Bramson, J.L.; Rullo, A.F. Molecular Therapy Oncology. 2024. DOI: 10.1016/j.omton.2024.200842

Offsetting Low-Affinity Carbohydrate Binding with Covalency to Engage Sugar-Specific Proteins for Tumor-Immune Proximity Induction

Lake, B. & Rullo, A.F. ACS Central Sci. 2023. DOI: 10.121/acscentsci.3c0152

A Modular Antibody-Oligomer T Cell Engager for Applications in Local Therapies

Marple, A.; Jesmer, A.; Lake, B.; Rullo, A.F.; Wylie, R. Advanced Therapeutics. 2023. DOI : 10.1002/adtp.202300124

Orchestrating Binding Interactions and the Emergence of Avidity Driven Therapeutics

Kapcan, E.; Lake, B.; Rullo, A.F. ACS Central Science. 2023. DOI: 10.1021/acscentsci.3c00242

A Covalent Opsonization Approach to Enhance Synthetic Immunity against Viral Escape Variants

Kapcan, E. & Rullo, A.F. Cell Reports Physical Sciences. 2022. DOI: 10.2139/ssrn.4273246

Tunable Synthetic Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers

Lake, B.; Wylie,R.; Bařinka, C.; Rullo, A.F. Angewandte International. 2022. DOI : 10.1002/anie.202214659

Covalent Immune Proximity-Induction Strategy Using SuFEx-Engineered Bifunctional Viral Peptides

McCann, H.; Lake, B.; Hoffman, K.; Davola, M.; Mossman K.; Rullo, A.F. ACS Chemical Biology. 2022. DOI: 10.1021/acschembio.2c00233

Development of a B-cell maturation antigen-specific T-cell antigen coupler receptor for multiple myeloma

Bezverbnaya, K.; Moogk, D.; Cummings, D.; Baker C. L.; Aarts, C.; Denisova, G.; Sun, M.; McNicol J.D.; Turner, R.C.; Rullo, A. F.; Foley, S. R.; Bramson, J.L. Cytotherapy. 2021. DOI: 10.1016/j.jcyt.2021.05.007

A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules

Rathmann, S. M.; Genady, A. R.; Janzen, N.; Anipindi, V.; Czorny, S.; Rullo, A. F.; Sadeghi, S.; Valliant, J. F. 2021. DOI: 10.1021/acs.molpharmaceut.1c00187

Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets

Kapcan, E.; Lake, B.; Yang, Z.; Zhang, A.; Miller, M. S.; Rullo, A. F. Biochemistry. 2021. DOI: acs.biochem.1c00127.

Cell-Specific Drug Targeting in the Lung

Abed S, Turner R, Serniuck N, Tat V, Naiel S, Hayat A, Mekhael O, Vierhout M, Ask K, Rullo AF. Biochem. Pharmoacol. 2021;114577. DOI: 10.1016/j.bcp.2021.114577

Investigating Synthetic Immune Recruitment by Proximity Inducing Molecules: Validation of Covalent Immune Recruiters (CIRs) Function Using the Octet® Platform

Kapcan E, Yang Z, Lake B, Rullo AF.

Methods to Validate Binding and Kinetics of “Proximity‐Inducing” Covalent Immune‐Recruiting Molecules Kapcan E, Lake B, Yang Z, Rullo AF. Current Protocols in Chemical Biology. 2020. DOI:10.1002/cpch.88

Covalent Immune Recruiters (CIRs): Tools to Gain Chemical Control Over Immune Recognition. Lake B, Serniuck N, Kapcan E, Wang A, Rullo AF. ACS Chemical Biology. 2020. DOI:10.1021/acschembio.0c00112

Improved Efficacy of Antibody Cancer Immunotherapeutics through Local and Sustained Delivery Huynh V, Jesmer AH, Shoaib MM, D'Angelo AD, Rullo AF, Wylie RG. ChemBioChem . 2019; 20(6):747-53. PMID: 30426647 DOI: 10.1002/cbic.201800579

Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor.
Rullo AF, Fitzgerald KJ, Muthusamy V, Liu M, Yuan C, Huang M, Kim M, Cho AE, Spiegel DA.
Angewandte Chemie (International ed. in English). 2016; 55(11):3642-6. NIHMSID: NIHMS901305
PubMed [journal]PMID: 26879524 PMCID: PMC5597302

Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative.
Rullo A, Reiner A, Reiter A, Trauner D, Isacoff EY, Woolley GA.
Chemical communications (Cambridge, England). 2014; 50(93):14613-5.
PubMed [journal]PMID: 25311049

Site-selective affinity labelling of maltose binding protein in bacterial cells.
Rullo A, Beharry AA, Gómez-Biagi RF, Zhao X, Nitz M.
Chembiochem : a European journal of chemical biology. 2012; 13(6):783-7.
PubMed [journal]PMID: 22378590

Peptide-glycosaminoglycan cluster formation involving cell penetrating peptides.
Rullo A, Qian J, Nitz M.
Biopolymers. 2011; 95(10):722-31.
PubMed [journal]PMID: 21538329

Fluorescence resonance energy transfer in gaseous, mass-selected polyproline peptides.
Talbot FO, Rullo A, Yao H, Jockusch RA.
Journal of the American Chemical Society. 2010; 132(45):16156-64.
PubMed [journal]PMID: 20964374

Importance of the spatial display of charged residues in heparin-peptide interactions.
Rullo A, Nitz M.
Biopolymers. 2010; 93(3):290-8.
PubMed [journal]PMID: 19885920

Heparin dependent coiled-coil formation.
Nitz M, Rullo A, Ding MX.
Chembiochem : a European journal of chemical biology. 2008; 9(10):1545-8.
PubMed [journal]PMID: 18506865

Development of an impregnated reagent and automation of solid-phase analytical derivatization for carbonyls: proof of principle.
Rosenfeld J, Kim M, Rullo A.
Journal of chromatographic science. 2006; 44(6):333-9.
PubMed [journal]PMID: 16884588

The structural basis for the serospecificity of Actinobacillus suis serogroup O:2.
Rullo A, Papp-Szabo E, Michael FS, Macinnes J, Monteiro MA.
Biochemistry and cell biology = Biochimie et biologie cellulaire. 2006; 84(2):184-90.
PubMed [journal]PMID: 16609699